Laboratorio de Biología Molecular de Parásitos

Responsable: Dr. José F. Tort

Publicaciones

  • Role of the prosegment of Fasciola hepatica cathepsin L1 in folding of the catalytic domain

    Mónica Cappetta, Ivana Roth, Alvaro Díaz, José Tort, Leda Roche
    Abstract

  • A distinctive repertoire of cathepsins is expressed by juvenile invasive Fasciola hepatica

    Martín Cancela, Daniel Acosta, Gabriel Rinaldi, Edileusa Silva, Rosario Durán, Leda Roche, Arnaldo Zaha, Carlos Carmona, Jose F Tort
    Abstract

  • The major cathepsin L secreted by the invasive juvenile Fasciola hepatica prefers proline in the S2 subsite and can cleave collagen

    Ileana Corvo, Martín Cancela, Mónica Cappetta, Natalia Pi-Denis, José F Tort, Leda Roche
    Abstract

  • Dissecting the active site of the collagenolytic cathepsin L3 protease of the invasive stage of Fasciola hepatica

    Ileana Corvo, Anthony J O'Donoghue, Lucía Pastro, Natalia Pi-Denis, Alegra Eroy-Reveles, Leda Roche, James H McKerrow, John P Dalton, Charles S Craik, Conor R Caffrey, José F Tort
    Abstract

  • RNA interference in Fasciola hepatica newly excysted juveniles: long dsRNA induces more persistent silencing than siRNA

    Nicolás Dell'Oca, Tatiana Basika, Ileana Corvo, Estela Castillo, Paul J Brindley, Gabriel Rinaldi, Jose F Tort
    Abstract

  • The miRnome of Fasciola hepatica juveniles endorses the existence of a reduced set of highly divergent micro RNAs in parasitic flatworms

    Santiago Fontenla, Nicolás Dell'Oca, Pablo Smircich, José F Tort, Mar Siles-Lucas
    Abstract

  • Fasciola hepatica mucin-encoding gene: expression, variability and its potential relevance in host-parasite relationship

    Martín Cancela, Guilherme B Santos, Carlos Carmona, Henrique B Ferreira, José Francisco Tort, Arnaldo Zaha
    Abstract

  • Identification of Chalcones as Fasciola hepatica Cathepsin L Inhibitors Using a Comprehensive Experimental and Computational Approach

    Florencia Ferraro, Alicia Merlino, Nicolás Dell Oca, Jorge Gil, José F Tort, Mercedes Gonzalez, Hugo Cerecetto, Mauricio Cabrera, Ileana Corvo
    Abstract

  • Fasciolosis in South America: epidemiology and control challenges

    C Carmona, J F Tort
    Abstract

  • Genomes of Fasciola hepatica from the Americas Reveal Colonization with Neorickettsia Endobacteria Related to the Agents of Potomac Horse and Human Sennetsu Fevers

    Samantha N McNulty, Jose F Tort, Gabriel Rinaldi, Kerstin Fischer, Bruce A Rosa, Pablo Smircich, Santiago Fontenla, Young-Jun Choi, Rahul Tyagi, Kymberlie Hallsworth-Pepin, Victoria H Mann, Lakshmi Kammili, Patricia S Latham, Nicolas Dell'Oca, Fernanda…
    Abstract

  • Functional characterization of single-domain cystatin-like cysteine proteinase inhibitors expressed by the trematode Fasciola hepatica

    Martín Cancela, Ileana Corvo, Edileuza DA Silva, Aline Teichmann, Leda Roche, Alvaro Díaz, José Fransisco Tort, Henrique B Ferreira, Arnaldo Zaha
    Abstract

  • Conservation and diversification of small RNA pathways within flatworms

    Santiago Fontenla, Gabriel Rinaldi, Pablo Smircich, Jose F Tort
    Abstract

  • Expression, purification and characterization of two leucine aminopeptidases of the blood fluke, Schistosoma mansoni

    Gabriela Maggioli, Gabriel Rinaldi, Ines Giaudrone, Patricia Berasain, José F Tort, Paul J Brindley, Carlos Carmona
    Abstract

  • Pleiotropic alterations in gene expression in Latin American Fasciola hepatica isolates with different susceptibility to drugs

    Santiago Radio, Santiago Fontenla, Victoria Solana, Anna C Matos Salim, Flávio Marcos Gomes Araújo, Pedro Ortiz, Cristian Hoban, Estefan Miranda, Valeria Gayo, Fabiano Sviatopolk-Mirsky Pais, Hugo Solana, Guilherme Oliveira, Pablo Smircich, José F Tort
    Abstract

  • Substrate Specificity of Cysteine Proteases Beyond the S2 Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L

    Ileana Corvo, Florencia Ferraro, Alicia Merlino, Kathrin Zuberbühler, Anthony J O'Donoghue, Lucía Pastro, Natalia Pi-Denis, Tatiana Basika, Leda Roche, James H McKerrow, Charles S Craik, Conor R Caffrey, José F Tort
    Abstract

  • Different SNPs in Fasciola hepatica P-glycoprotein from diverse Latin American populations are not associated with Triclabendazole resistance

    María Victoria Solana, María Fernanda Domínguez, Silvana Scarcella, Santiago Radio, Pablo Smircich, Silvina Fernández, Hugo Solana, José F Tort
    Abstract

  • Cathepsin L3 From Fasciola hepatica Induces NLRP3 Inflammasome Alternative Activation in Murine Dendritic Cells

    Daiana Pamela Celias, Ileana Corvo, Leonardo Silvane, José Francisco Tort, Laura Silvina Chiapello, Manuel Fresno, Alicia Arranz, Claudia Cristina Motrán, Laura Cervi
    Abstract

  • Adaptive Radiation of the Flukes of the Family Fasciolidae Inferred from Genome-Wide Comparisons of Key Species

    Young-Jun Choi, Santiago Fontenla, Peter U Fischer, Thanh Hoa Le, Alicia Costábile, David Blair, Paul J Brindley, Jose F Tort, Miguel M Cabada, Makedonka Mitreva
    Abstract

  • Compositional Analysis of Flatworm Genomes Shows Strong Codon Usage Biases Across All Classes

    Guillermo Lamolle, Santiago Fontenla, Gastón Rijo, Jose F Tort, Pablo Smircich
    Abstract

  • Design of a Peptide-Carrier Vaccine Based on the Highly Immunogenic Fasciola hepatica Leucine Aminopeptidase

    Cecilia Salazar, José F Tort, Carlos Carmona
    Abstract

  • Gene Silencing in the Liver Fluke Fasciola hepatica: RNA Interference

    Gabriel Rinaldi, Nicolás Dell'Oca, Estela Castillo, José F Tort
    Abstract

  • Editorial: Novel Frontiers in Helminth Genomics

    Jose F Tort, Makedonka Mitreva, Klaus R Brehm, Gabriel Rinaldi
    Abstract

  • Lost and Found: Piwi and Argonaute Pathways in Flatworms

    Santiago Fontenla, Gabriel Rinaldi, Jose F Tort
    Abstract

Integrantes

  • Dr. José F. Tort
    Profesor (Grado 5)
    jtort@fmed.edu.uy
  • Dra. Fernanda Domínguez
    Asistente (Grado 2)
  • Dr. Santiago Fontenla
    Asistente (Grado 2)
    sfontenla@fmed.edu.uy
  • Br. Agustín Bilat
    Ayudante (Grado 1)
  • Br. Carla Molles
    Ayudante (Grado 1)
  • Lic. Gastón Rijo
    Ex - Grado 1, Colaborador
    grijo@fmed.edu.uy
  • Dr. Guillermo Lamolle
    Asistente contratado (Grado 2)

Departamento de Genética. Facultad de Medicina - Universidad de la República 
Avenida General Flores 2125 C.P. 11800 Montevideo - Uruguay 
Tel.: (+598) 2924 3414 Interno 3469.